Identification and characterization of heteroclitic peptides in TCR-binding positions with improved HLA-binding efficacy

Identification and characterization of heteroclitic peptides in TCR-binding positions with improved HLA-binding efficacy

Abstract The antigenicity as well as the immunogenicity of tumor associated antigens (TAAs) may need to be potentiated in order to break the immunological tolerance. To this aim, heteroclitic peptides were designed introducing specific substitutions in the residue at position 4 (p4) binding to TCR....

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Bibliographic Details
Main Authors: Beatrice Cavalluzzo, Concetta Ragone, Angela Mauriello, Annacarmen Petrizzo, Carmen Manolio, Andrea Caporale, Luigi Vitagliano, Menotti Ruvo, Luigi Buonaguro, Maria Tagliamonte
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Journal of Translational Medicine
Online Access:https://doi.org/10.1186/s12967-021-02757-x

Internet

https://doi.org/10.1186/s12967-021-02757-x

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