SETD8C302R Mutation Revealed from Myofibroblastoma‐Discordant Monozygotic Twins Leads to p53/p21 Deficit and WEE1 Inhibitor Sensitivity

SETD8C302R Mutation Revealed from Myofibroblastoma‐Discordant Monozygotic Twins Leads to p53/p21 Deficit and WEE1 Inhibitor Sensitivity

Abstract High‐throughput gene sequencing has identified various genetic variants as the culprits for some common hereditary cancers. However, the heritability of a substantial proportion of cancers remains unexplained, which may result from rare deleterious mutations hidden in a myriad of nonsense g...

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Bibliographic Details
Main Authors: Miao Li, Hongwu Wang, Hongwei Liao, Jiaxin Shen, Yinfang Wu, Yanping Wu, Qingyu Weng, Chen Zhu, Xinwei Geng, Fen Lan, Yang Xia, Bin Zhang, Hang Zou, Nan Zhang, Yunzhi Zhou, Zhihua Chen, Huahao Shen, Songmin Ying, Wen Li
Format: Article
Language:English
Published: Wiley 2020-10-01
Series:Advanced Science
Subjects:
genome instability | p53/p21 | rare mutations | SETD8 | WEE1 inhibition
Online Access:https://doi.org/10.1002/advs.202001041

Internet

https://doi.org/10.1002/advs.202001041

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