Drug Screening and Drug Repositioning as Promising Therapeutic Approaches for Spinal Muscular Atrophy Treatment

Drug Screening and Drug Repositioning as Promising Therapeutic Approaches for Spinal Muscular Atrophy Treatment

Spinal muscular atrophy (SMA) is the most common genetic disease affecting infants and young adults. Due to mutation/deletion of the survival motor neuron (SMN) gene, SMA is characterized by the SMN protein lack, resulting in motor neuron impairment, skeletal muscle atrophy and premature death. Even...

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Bibliographic Details
Main Authors: Giovanna Menduti, Daniela Maria Rasà, Serena Stanga, Marina Boido
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Pharmacology
Subjects:
survival motor neuron
motor neuron disease
therapy
cell death and degradation
mitochondria
cytoskeleton dynamics
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.592234/full

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https://www.frontiersin.org/articles/10.3389/fphar.2020.592234/full

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