Synthesis and Cytotoxic Activity of Novel Indole Derivatives and Their in silico Screening on Spike Glycoprotein of SARS-CoV-2

Synthesis and Cytotoxic Activity of Novel Indole Derivatives and Their in silico Screening on Spike Glycoprotein of SARS-CoV-2

This work investigated the interaction of indole with SARS-CoV-2. Indole is widely used as a medical material owing to its astounding biological activities. Indole and its derivatives belong to a significant category of heterocyclic compounds that have been used as a crucial component for several sy...

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Bibliographic Details
Main Authors: Perumal Gobinath, Ponnusamy Packialakshmi, Kaliappillai Vijayakumar, Magda H. Abdellattif, Mohd Shahbaaz, Akbar Idhayadhulla, Radhakrishnan Surendrakumar
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Molecular Biosciences
Subjects:
indole
Mannich base
cytotoxic activity
COVID-19
spike protein
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.637989/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.637989/full

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