Multifunctional Nanoregulator Reshapes Immune Microenvironment and Enhances Immune Memory for Tumor Immunotherapy

Multifunctional Nanoregulator Reshapes Immune Microenvironment and Enhances Immune Memory for Tumor Immunotherapy

Abstract Hypoxia leads to up‐regulation of PD‐L1 and decreases T lymphocyte infiltration, thus boosting immunotherapeutic resistance of tumors. Moreover, tumor‐infiltrating myeloid cells such as myeloid‐derived suppressor cells (MDSCs) correlate with potent immune suppressive activity and resistance...

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Bibliographic Details
Main Authors: Meng Yu, Xiaohui Duan, Yujun Cai, Fang Zhang, Shuqi Jiang, Shisong Han, Jun Shen, Xintao Shuai
Format: Article
Language:English
Published: Wiley 2019-08-01
Series:Advanced Science
Subjects:
hypoxia
myeloid‐derived suppressor cells
PI3Kγ inhibitor
triggered release
tumor immune microenvironment
Online Access:https://doi.org/10.1002/advs.201900037

Internet

https://doi.org/10.1002/advs.201900037

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