Derived (Mutated)–Types of TRPV6 Channels Elicit Greater Ca2+ Influx Into the Cells Than Ancestral-Types of TRPV6: Evidence From Xenopus Oocytes and Mammalian Cell Expression System
Abstract.: The frequency of the allele containing three derived nonsynonymous SNPs (157C, 378M, 681M) of the gene encoding calcium permeable TRPV6 channels expressed in the intestine has been increased by positive selection in non-African populations. To understand the nature of these SNPs, we compa...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2010-01-01
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| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319308394 |