Integrin α5β1, the Fibronectin Receptor, as a Pertinent Therapeutic Target in Solid Tumors

Integrin α5β1, the Fibronectin Receptor, as a Pertinent Therapeutic Target in Solid Tumors

Integrins are transmembrane heterodimeric proteins sensing the cell microenvironment and modulating numerous signalling pathways. Changes in integrin expression between normal and tumoral cells support involvement of specific integrins in tumor progression and aggressiveness. This review highlights...

Full description

Bibliographic Details
Main Authors: Monique Dontenwill, Anne Marie Ray, Florence Schaffner
Format: Article
Language:English
Published: MDPI AG 2013-01-01
Series:Cancers
Subjects:
&#945
5&#946
1
integrin
fibronectin receptor
solid tumors
angiogenesis
antagonists
Online Access:http://www.mdpi.com/2072-6694/5/1/27

Internet

http://www.mdpi.com/2072-6694/5/1/27

Similar Items