Time-Resolved Transcriptomics and Constraint-Based Modeling Identify System-Level Metabolic Features and Overexpression Targets to Increase Spiramycin Production in Streptomyces ambofaciens

Time-Resolved Transcriptomics and Constraint-Based Modeling Identify System-Level Metabolic Features and Overexpression Targets to Increase Spiramycin Production in Streptomyces ambofaciens

In this study we have applied an integrated system biology approach to characterize the metabolic landscape of Streptomyces ambofaciens and to identify a list of potential metabolic engineering targets for the overproduction of the secondary metabolites in this microorganism. We focused on an often...

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Bibliographic Details
Main Authors: Marco Fondi, Eva Pinatel, Adelfia Talà, Fabrizio Damiano, Clarissa Consolandi, Benedetta Mattorre, Daniela Fico, Mariangela Testini, Giuseppe E. De Benedetto, Luisa Siculella, Gianluca De Bellis, Pietro Alifano, Clelia Peano
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Microbiology
Subjects:
Streptomyces ambofaciens
antibiotic production
strain improvement
metabolic modeling
transcriptomics
systems biology
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2017.00835/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2017.00835/full

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