Optogenetic activation of parvalbumin and somatostatin interneurons selectively restores theta-nested gamma oscillations and oscillation-induced spike timing-dependent long-term potentiation impaired by amyloid β oligomers

Optogenetic activation of parvalbumin and somatostatin interneurons selectively restores theta-nested gamma oscillations and oscillation-induced spike timing-dependent long-term potentiation impaired by amyloid β oligomers

Abstract Background Abnormal accumulation of amyloid β1–42 oligomers (AβO1–42), a hallmark of Alzheimer’s disease, impairs hippocampal theta-nested gamma oscillations and long-term potentiation (LTP) that are believed to underlie learning and memory. Parvalbumin-positive (PV) and somatostatin-positi...

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Bibliographic Details
Main Authors: Kyerl Park, Jaedong Lee, Hyun Jae Jang, Blake A. Richards, Michael M. Kohl, Jeehyun Kwag
Format: Article
Language:English
Published: BMC 2020-01-01
Series:BMC Biology
Subjects:
Alzheimer’s disease
Amyloid beta oligomers
Hippocampus
Optogenetics
Parvalbumin interneuron
Somatostatin interneuron
Online Access:https://doi.org/10.1186/s12915-019-0732-7

Internet

https://doi.org/10.1186/s12915-019-0732-7

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