Low-level alternative tRNA priming of reverse transcription of HIV-1 and SIV in vivo

Low-level alternative tRNA priming of reverse transcription of HIV-1 and SIV in vivo

Abstract Background Reverse transcription (RT) of HIV and SIV is initiated by the binding of the acceptor stem of tRNALys3 to the primer binding site (PBS) of the viral RNA genome. Previous studies have suggested that this tRNALys3 is not the only molecule capable of priming reverse transcription, a...

Full description

Bibliographic Details
Main Authors: Christine M. Fennessey, Celine Camus, Taina T. Immonen, Carolyn Reid, Frank Maldarelli, Jeffrey D. Lifson, Brandon F. Keele
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Retrovirology
Subjects:
SIV
HIV
Primer binding site
tRNA
Next-generation deep-sequencing
Online Access:http://link.springer.com/article/10.1186/s12977-019-0473-2

Internet

http://link.springer.com/article/10.1186/s12977-019-0473-2

Similar Items