Brain-derived neurotrophic factor rescues and prevents chronic intermittent hypoxia-induced impairment of hippocampal long-term synaptic plasticity

Brain-derived neurotrophic factor rescues and prevents chronic intermittent hypoxia-induced impairment of hippocampal long-term synaptic plasticity

Obstructive sleep apnea (OSA) is a common sleep and breathing disorder characterized by repeated episodes of hypoxemia. OSA causes neurocognitive deficits including perception and memory impairment but the underlying mechanisms are unknown. Here we show that in a mouse model of OSA, chronic intermit...

Full description

Bibliographic Details
Main Authors: Hui Xie, Kin-Ling Leung, Lei Chen, Ying-Shing Chan, Pak-Cheung Ng, Tai-Fai Fok, Yun-Kwok Wing, Ya Ke, Albert M. Li, Wing-Ho Yung
Format: Article
Language:English
Published: Elsevier 2010-10-01
Series:Neurobiology of Disease
Subjects:
Intermittent hypoxia
Sleep apnea
BDNF
LTP
Synaptic plasticity
Neurotrophic factor
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110001828

Internet

http://www.sciencedirect.com/science/article/pii/S0969996110001828

Similar Items