Biomechanical Conditioning Enhanced Matrix Synthesis in Nucleus Pulposus Cells Cultured in Agarose Constructs with TGFβ

Biomechanical Conditioning Enhanced Matrix Synthesis in Nucleus Pulposus Cells Cultured in Agarose Constructs with TGFβ

Biomechanical signals play an important role in normal disc metabolism and pathology. For instance, nucleus pulposus (NP) cells will regulate metabolic activities and maintain a balance between the anabolic and catabolic cascades. The former involves factors such as transforming growth factor-β (TGF...

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Bibliographic Details
Main Authors: Tina T. Chowdhury, Dan L. Bader, Reshma K. Tilwani
Format: Article
Language:English
Published: MDPI AG 2012-01-01
Series:Journal of Functional Biomaterials
Subjects:
TGFβ
mechanical loading
matrix synthesis
nucleus pulposus
intervertebral disc
Online Access:http://www.mdpi.com/2079-4983/3/1/23/

Internet

http://www.mdpi.com/2079-4983/3/1/23/

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