Inhibition of mTORC1 Enhances the Translation of Chikungunya Proteins via the Activation of the MnK/eIF4E Pathway.

Inhibition of mTORC1 Enhances the Translation of Chikungunya Proteins via the Activation of the MnK/eIF4E Pathway.

Chikungunya virus (CHIKV), the causative agent of a major epidemic spanning five continents, is a positive stranded mRNA virus that replicates using the cell's cap-dependent translation machinery. Despite viral infection inhibiting mTOR, a metabolic sensor controls cap-dependent translation, vi...

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Bibliographic Details
Main Authors: Pierre-Emmanuel Joubert, Kenneth Stapleford, Florence Guivel-Benhassine, Marco Vignuzzi, Olivier Schwartz, Matthew L Albert
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-08-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4552638?pdf=render

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http://europepmc.org/articles/PMC4552638?pdf=render

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