Suppression of astrocytic autophagy by αB-crystallin contributes to α-synuclein inclusion formation

Suppression of astrocytic autophagy by αB-crystallin contributes to α-synuclein inclusion formation

Abstract Background Parkinson’s disease (PD) is characterized by a chronic loss of dopaminergic neurons and the presence of proteinaceous inclusions (Lewy bodies) within some remaining neurons in the substantia nigra. Recently, astroglial inclusion body has also been found in some neurodegenerative...

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Bibliographic Details
Main Authors: Shen-zhao Lu, Yong-shun Guo, Pei-zhou Liang, Shu-zhen Zhang, Shu Yin, Yan-qing Yin, Xiao-min Wang, Fei Ding, Xiao-song Gu, Jia-wei Zhou
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Translational Neurodegeneration
Subjects:
αB-crystallin
Astrocytes
Parkinson’s disease
Autophagy
Online Access:http://link.springer.com/article/10.1186/s40035-018-0143-7

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http://link.springer.com/article/10.1186/s40035-018-0143-7

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