Host CD39 Deficiency Affects Radiation-Induced Tumor Growth Delay and Aggravates Radiation-Induced Normal Tissue Toxicity

Host CD39 Deficiency Affects Radiation-Induced Tumor Growth Delay and Aggravates Radiation-Induced Normal Tissue Toxicity

The ectonucleoside triphosphate diphosphohydrolase (CD39)/5′ ectonuclotidase (CD73)-dependent purinergic pathway emerges as promising cancer target. Yet, except for own previous work revealing a pathogenic role of CD73 and adenosine in radiation-induced lung fibrosis, the role of purinergic signalin...

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Bibliographic Details
Main Authors: Alina V. Meyer, Diana Klein, Simone de Leve, Klaudia Szymonowicz, Martin Stuschke, Simon C. Robson, Verena Jendrossek, Florian Wirsdörfer
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Oncology
Subjects:
ionizing radiation
purinergic signaling
CD73
cancer
ATP
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.554883/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2020.554883/full

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