Functional analysis and cryo-electron microscopy of Campylobacter jejuni serine protease HtrA

Functional analysis and cryo-electron microscopy of Campylobacter jejuni serine protease HtrA

Campylobacter jejuni is a predominant zoonotic pathogen causing gastroenteritis and other diseases in humans. An important bacterial virulence factor is the secreted serine protease HtrA (HtrACj), which targets tight and adherens junctional proteins in the gut epithelium. Here we have investigated t...

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Bibliographic Details
Main Authors: Urszula Zarzecka, Alessandro Grinzato, Eaazhisai Kandiah, Dominik Cysewski, Paola Berto, Joanna Skorko-Glonek, Giuseppe Zanotti, Steffen Backert
Format: Article
Language:English
Published: Taylor & Francis Group 2020-11-01
Series:Gut Microbes
Subjects:
campylobacter jejuni
htra
protease
oligomerization
cryo-em
cleavage site specificity
thermal stability
Online Access:http://dx.doi.org/10.1080/19490976.2020.1810532

Internet

http://dx.doi.org/10.1080/19490976.2020.1810532

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