Ion Channels Involved in Substance P-Mediated Nociception and Antinociception

Substance P (SP), an 11-amino-acid neuropeptide, has long been considered an effector of pain. However, accumulating studies have proposed a paradoxical role of SP in anti-nociception. Here, we review studies of SP-mediated nociception and anti-nociception in terms of peptide features, SP-modulated...

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Bibliographic Details
Main Authors: Chu-Ting Chang, Bo-Yang Jiang, Chih-Cheng Chen
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:https://www.mdpi.com/1422-0067/20/7/1596