A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism

A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism

Human liver chimeric mice are increasingly used for drug testing in preclinical development, but express residual murine p450 cytochromes. Here the authors generate mice lacking the Por gene in the liver, and show that human cytochrome metabolism is used following repopulation with human hepatocytes...

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Bibliographic Details
Main Authors: Mercedes Barzi, Francis P. Pankowicz, Barry Zorman, Xing Liu, Xavier Legras, Diane Yang, Malgorzata Borowiak, Beatrice Bissig-Choisat, Pavel Sumazin, Feng Li, Karl-Dimiter Bissig
Format: Article
Language:English
Published: Nature Publishing Group 2017-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00049-x

Internet

https://doi.org/10.1038/s41467-017-00049-x

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