Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways

Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways

Abstract Background The mitochondrial unfolded protein response (mitoUPR) is a stress response pathway activated by disruption of proteostasis in the mitochondria. This pathway has been proposed to influence lifespan, with studies suggesting that mitoUPR activation has complex effects on longevity....

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Bibliographic Details
Main Authors: Ziyun Wu, Megan M. Senchuk, Dylan J. Dues, Benjamin K. Johnson, Jason F. Cooper, Leira Lew, Emily Machiela, Claire E. Schaar, Heather DeJonge, T. Keith Blackwell, Jeremy M. Van Raamsdonk
Format: Article
Language:English
Published: BMC 2018-12-01
Series:BMC Biology
Subjects:
Aging
Lifespan
Mitochondria
C. elegans
Mitochondrial unfolded protein response
ATFS-1
Online Access:http://link.springer.com/article/10.1186/s12915-018-0615-3

Internet

http://link.springer.com/article/10.1186/s12915-018-0615-3

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