Kinetics of Flavoenzyme-Catalyzed Reduction of Tirapazamine Derivatives: Implications for Their Prooxidant Cytotoxicity

Kinetics of Flavoenzyme-Catalyzed Reduction of Tirapazamine Derivatives: Implications for Their Prooxidant Cytotoxicity

Derivatives of tirapazamine and other heteroaromatic <i>N-</i>oxides (ArN&#8594;O) exhibit promising antibacterial, antiprotozoal, and tumoricidal activities. Their action is typically attributed to bioreductive activation and free radical generation. In this work, we aimed to clarif...

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Bibliographic Details
Main Authors: Aušra Nemeikaitė-Čėnienė, Jonas Šarlauskas, Violeta Jonušienė, Audronė Marozienė, Lina Misevičienė, Aliaksei V. Yantsevich, Narimantas Čėnas
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:International Journal of Molecular Sciences
Subjects:
tirapazamine
reductive activation
oxidative stress
cytotoxicity
Online Access:https://www.mdpi.com/1422-0067/20/18/4602

Internet

https://www.mdpi.com/1422-0067/20/18/4602

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