Mitigation of augmented extrasynaptic NMDAR signaling and apoptosis in cortico-striatal co-cultures from Huntington's disease mice

Mitigation of augmented extrasynaptic NMDAR signaling and apoptosis in cortico-striatal co-cultures from Huntington's disease mice

We recently reported evidence for disturbed synaptic versus extrasynaptic NMDAR transmission in the early pathogenesis of Huntington's disease (HD), a late-onset neurodegenerative disorder caused by CAG repeat expansion in the gene encoding huntingtin. Studies in glutamatergic cells indicate th...

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Bibliographic Details
Main Authors: Austen J. Milnerwood, Alexandra M. Kaufman, Marja D. Sepers, Clare M. Gladding, Lily Zhang, Liang Wang, Jing Fan, Ainsley Coquinco, Joy Yi Qiao, Hwan Lee, Yu Tian Wang, Max Cynader, Lynn A. Raymond
Format: Article
Language:English
Published: Elsevier 2012-10-01
Series:Neurobiology of Disease
Subjects:
NMDA receptor
GluN2A
GluN2B
Huntington's disease
Neurodegeneration
Striatal medium spiny neuron
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112001994

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http://www.sciencedirect.com/science/article/pii/S0969996112001994

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