RNA Expression of DNA Damage Response Genes in Muscle-Invasive Bladder Cancer: Influence on Outcome and Response to Adjuvant Cisplatin-Based Chemotherapy

RNA Expression of DNA Damage Response Genes in Muscle-Invasive Bladder Cancer: Influence on Outcome and Response to Adjuvant Cisplatin-Based Chemotherapy

Background: Perioperative cisplatin-based chemotherapy (CBC) can improve the outcome of patients with muscle-invasive bladder cancer (MIBC), but it is still to be defined which patients benefit. Mutations in DNA damage response genes (DDRG) can predict the response to CBC. The value of DDRG expressi...

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Bibliographic Details
Main Authors: Jonas Herrmann, Helena Schmidt, Katja Nitschke, Cleo-Aron Weis, Philipp Nuhn, Jost von Hardenberg, Maurice Stephan Michel, Philipp Erben, Thomas Stefan Worst
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
muscle-invasive bladder cancer
DNA-damage response
<i>BCL2</i>
<i>BRCA1</i>
<i>BRCA2</i>
<i>ERCC2</i>
Online Access:https://www.mdpi.com/1422-0067/22/8/4188

Internet

https://www.mdpi.com/1422-0067/22/8/4188

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