Mice with hypomorphic expression of the sodium-phosphate cotransporter PiT1/Slc20a1 have an unexpected normal bone mineralization.

Mice with hypomorphic expression of the sodium-phosphate cotransporter PiT1/Slc20a1 have an unexpected normal bone mineralization.

The formation of hydroxyapatite crystals and their insertion into collagen fibrils of the matrix are essential steps for bone mineralization. As phosphate is a main structural component of apatite crystals, its uptake by skeletal cells is critical and must be controlled by specialized membrane prote...

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Bibliographic Details
Main Authors: Annabelle Bourgine, Paul Pilet, Sara Diouani, Sophie Sourice, Julie Lesoeur, Sarah Beck-Cormier, Solmaz Khoshniat, Pierre Weiss, Gérard Friedlander, Jérôme Guicheux, Laurent Beck
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23785462/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23785462/?tool=EBI

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