Decreased store operated Ca2+ entry in dendritic cells isolated from mice expressing PKB/SGK-resistant GSK3.

Decreased store operated Ca2+ entry in dendritic cells isolated from mice expressing PKB/SGK-resistant GSK3.

Dendritic cells (DCs), key players of immunity, are regulated by glycogen synthase kinase GSK3. GSK3 activity is suppressed by PKB/Akt and SGK isoforms, which are in turn stimulated by the PI3K pathway. Exposure to bacterial lipopolysaccharides increases cytosolic Ca(2+)-concentration ([Ca(2+)]i), a...

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Bibliographic Details
Main Authors: Evi Schmid, Jing Yan, Meerim K Nurbaeva, Antonella Russo, Wenting Yang, Caterina Faggio, Ekaterina Shumilina, Florian Lang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3921210?pdf=render

Internet

http://europepmc.org/articles/PMC3921210?pdf=render

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