Cyclic Marinopyrrole Derivatives as Disruptors of Mcl-1 and Bcl-xL Binding to Bim

Cyclic Marinopyrrole Derivatives as Disruptors of Mcl-1 and Bcl-xL Binding to Bim

A series of novel cyclic marinopyrroles were designed and synthesized. Their activity to disrupt the binding of the pro-apoptotic protein, Bim, to the pro-survival proteins, Mcl-1 and Bcl-xL, was evaluated using ELISA assays. Both atropisomers of marinopyrrole A (1) show similar potency. A tetrabrom...

Full description

Bibliographic Details
Main Authors: Chunwei Cheng, Yan Liu, Maria E. Balasis, Nicholas L. Simmons, Jerry Li, Hao Song, Lili Pan, Yong Qin, K. C. Nicolaou, Said M. Sebti, Rongshi Li
Format: Article
Language:English
Published: MDPI AG 2014-03-01
Series:Marine Drugs
Subjects:
cyclic marinopyrroles
protein-protein interaction disruptors
apoptosis
SAR
Online Access:http://www.mdpi.com/1660-3397/12/3/1335

Internet

http://www.mdpi.com/1660-3397/12/3/1335

Similar Items