Dihydroergotamine inhibits the vasodepressor sensory CGRPergic outflow by prejunctional activation of α2-adrenoceptors and 5-HT1 receptors

Dihydroergotamine inhibits the vasodepressor sensory CGRPergic outflow by prejunctional activation of α2-adrenoceptors and 5-HT1 receptors

Abstract Background Dihydroergotamine (DHE) is an antimigraine drug that produces cranial vasoconstriction and inhibits trigeminal CGRP release; furthermore, it inhibits the vasodepressor sensory CGRPergic outflow, but the receptors involved remain unknown. Prejunctional activation of α2A/2C-adrener...

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Bibliographic Details
Main Authors: Abimael González-Hernández, Jair Lozano-Cuenca, Bruno A. Marichal-Cancino, Antoinette MaassenVanDenBrink, Carlos M. Villalón
Format: Article
Language:English
Published: BMC 2018-05-01
Series:The Journal of Headache and Pain
Subjects:
CGRP
Dihydroergotamine
Pithed rat
Sensory neurons
Vasodepressor responses
Online Access:http://link.springer.com/article/10.1186/s10194-018-0869-8

Internet

http://link.springer.com/article/10.1186/s10194-018-0869-8

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