Chemical modulation of transcriptionally enriched signaling pathways to optimize the conversion of fibroblasts into neurons

Chemical modulation of transcriptionally enriched signaling pathways to optimize the conversion of fibroblasts into neurons

Direct conversion of human somatic fibroblasts into induced neurons (iNs) allows for the generation of functional neurons while bypassing any stem cell intermediary stages. Although iN technology has an enormous potential for modeling age-related diseases, as well as therapeutic approaches, the tech...

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Bibliographic Details
Main Authors: Joseph Herdy, Simon Schafer, Yongsung Kim, Zoya Ansari, Dina Zangwill, Manching Ku, Apua Paquola, Hyungjun Lee, Jerome Mertens, Fred H Gage
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-05-01
Series:eLife
Subjects:
direct reprogramming
iN
transgenesis
pathway analysis
lentivirus
induced neurons
Online Access:https://elifesciences.org/articles/41356

Internet

https://elifesciences.org/articles/41356

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