Simple and Efficient Synthesis of Racemic 2-(tert-Butoxycarbon-ylamino)-2-methyl-3-(1H-1,2,4-triazol-1-yl)propanoic Acid, a New Derivative of β-(1,2,4-Triazol-1-yl)alanine

Simple and Efficient Synthesis of Racemic 2-(tert-Butoxycarbon-ylamino)-2-methyl-3-(1H-1,2,4-triazol-1-yl)propanoic Acid, a New Derivative of β-(1,2,4-Triazol-1-yl)alanine

A simple synthetic approach to racemic N-tert-butyloxycarbonyl-2-methyl-3-(1H-1,2,4-triazol-1-yl)alanine (5) in four steps and 68% overall yield starting from oxazoline derivative 1 is reported. This synthesis involves the alkylation of 1H-1,2,4-triazole with an O-tosyloxazoline derivative, followed...

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Bibliographic Details
Main Authors: Abdelali Kerbal, Abdelrhani Elachqar, Anouar Alami, Abdelilah El-Hallaoui, Younas Aouine, Hassane Faraj
Format: Article
Language:English
Published: MDPI AG 2011-04-01
Series:Molecules
Subjects:
oxazoline
1H-1,2,4-triazole
high regioselective alkylation
β‑aminoalcohol
β‑(1,2,4-triazol-1-yl)alanine
Online Access:http://www.mdpi.com/1420-3049/16/4/3380/

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http://www.mdpi.com/1420-3049/16/4/3380/

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