Pancreatic deletion of the interleukin-1 receptor disrupts whole body glucose homeostasis and promotes islet β-cell de-differentiation

Pancreatic deletion of the interleukin-1 receptor disrupts whole body glucose homeostasis and promotes islet β-cell de-differentiation

Objective: Pancreatic tissue, and islets in particular, are enriched in expression of the interleukin-1 receptor type I (IL-1R). Because of this enrichment, islet β-cells are exquisitely sensitive to the IL-1R ligands IL-1α and IL-1β, suggesting that signaling through this pathway regulates health a...

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Bibliographic Details
Main Authors: Susan J. Burke, Heidi M. Batdorf, David H. Burk, Thomas M. Martin, Tamra Mendoza, Krisztian Stadler, Wateen Alami, Michael D. Karlstad, Matthew J. Robson, Randy D. Blakely, Randall L. Mynatt, J. Jason Collier
Format: Article
Language:English
Published: Elsevier 2018-08-01
Series:Molecular Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877818303041

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http://www.sciencedirect.com/science/article/pii/S2212877818303041

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