Modeling of axonal endoplasmic reticulum network by spastic paraplegia proteins

Modeling of axonal endoplasmic reticulum network by spastic paraplegia proteins

Axons contain a smooth tubular endoplasmic reticulum (ER) network that is thought to be continuous with ER throughout the neuron; the mechanisms that form this axonal network are unknown. Mutations affecting reticulon or REEP proteins, with intramembrane hairpin domains that model ER membranes, caus...

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Bibliographic Details
Main Authors: Belgin Yalçın, Lu Zhao, Martin Stofanko, Niamh C O'Sullivan, Zi Han Kang, Annika Roost, Matthew R Thomas, Sophie Zaessinger, Olivier Blard, Alex L Patto, Anood Sohail, Valentina Baena, Mark Terasaki, Cahir J O'Kane
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-07-01
Series:eLife
Subjects:
endoplasmic reticulum
hereditary spastic paraplegia
axon
axon degeneration
ultrastructure
smooth endoplasmic reticulum
Online Access:https://elifesciences.org/articles/23882

Internet

https://elifesciences.org/articles/23882

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