The ectodomains determine ligand function in vivo and selectivity of DLL1 and DLL4 toward NOTCH1 and NOTCH2 in vitro

The ectodomains determine ligand function in vivo and selectivity of DLL1 and DLL4 toward NOTCH1 and NOTCH2 in vitro

DLL1 and DLL4 are Notch ligands with high structural similarity but context-dependent functional differences. Here, we analyze their functional divergence using cellular co-culture assays, biochemical studies, and in vivo experiments. DLL1 and DLL4 activate NOTCH1 and NOTCH2 differently in cell-base...

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Bibliographic Details
Main Authors: Lena Tveriakhina, Karin Schuster-Gossler, Sanchez M Jarrett, Marie B Andrawes, Meike Rohrbach, Stephen C Blacklow, Achim Gossler
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-10-01
Series:eLife
Subjects:
DLL1
DLL4
notch receptor selectivity
functional divergence
ectodomain
Online Access:https://elifesciences.org/articles/40045

Internet

https://elifesciences.org/articles/40045

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