High Level Expression and Purification of the Clinically Active Antimicrobial Peptide P-113 in Escherichia coli

High Level Expression and Purification of the Clinically Active Antimicrobial Peptide P-113 in Escherichia coli

P-113, which was originally derived from the human saliva protein histatin 5, is a histidine-rich antimicrobial peptide with the sequence AKRHHGYKRKFH. P-113 is currently undergoing phase II clinical trial as a pharmaceutical agent to fight against fungal infections in HIV patients with oral candidi...

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Bibliographic Details
Main Authors: Kuang-Ting Cheng, Chih-Lung Wu, Bak-Sau Yip, Hui-Yuan Yu, Hsi-Tsung Cheng, Ya-Han Chih, Jya-Wei Cheng
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Molecules
Subjects:
P-113
hG31P
expression
purification
NMR
Online Access:http://www.mdpi.com/1420-3049/23/4/800

Internet

http://www.mdpi.com/1420-3049/23/4/800

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