FUS Mutant Human Motoneurons Display Altered Transcriptome and microRNA Pathways with Implications for ALS Pathogenesis

FUS Mutant Human Motoneurons Display Altered Transcriptome and microRNA Pathways with Implications for ALS Pathogenesis

Summary: The FUS gene has been linked to amyotrophic lateral sclerosis (ALS). FUS is a ubiquitous RNA-binding protein, and the mechanisms leading to selective motoneuron loss downstream of ALS-linked mutations are largely unknown. We report the transcriptome analysis of human purified motoneurons, o...

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Bibliographic Details
Main Authors: Riccardo De Santis, Laura Santini, Alessio Colantoni, Giovanna Peruzzi, Valeria de Turris, Vincenzo Alfano, Irene Bozzoni, Alessandro Rosa
Format: Article
Language:English
Published: Elsevier 2017-11-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117304101

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http://www.sciencedirect.com/science/article/pii/S2213671117304101

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