Multifunctional Protein Conjugates with Built-in Adjuvant (Adjuvant-Protein-Antigen) as Cancer Vaccines Boost Potent Immune Responses

Summary: Many cancer vaccines are not successful in clinical trials, mainly due to the challenges associated with breaking immune tolerance. Herein, we report a new strategy using an adjuvant-protein-antigen (three-in-one protein conjugates with built-in adjuvant) as an anticancer vaccine, in which...

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Bibliographic Details
Main Authors: Jing-Jing Du, Chang-Wei Wang, Wen-Bo Xu, Lian Zhang, Yuan-Kai Tang, Shi-Hao Zhou, Xiao-Fei Gao, Guang-Fu Yang, Jun Guo
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422030119X