Endothelial expression of human ABCA1 in mice increases plasma HDL cholesterol and reduces diet-induced atherosclerosis[S]

Endothelial expression of human ABCA1 in mice increases plasma HDL cholesterol and reduces diet-induced atherosclerosis[S]

The role of endothelial ABCA1 expression in reverse cholesterol transport (RCT) was examined in transgenic mice, using the endothelial-specific Tie2 promoter. Human ABCA1 (hABCA1) was significantly expressed in endothelial cells (EC) of most tissues except the liver. Increased expression of ABCA1 wa...

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Bibliographic Details
Main Authors: Boris L. Vaisman, Stephen J. Demosky, John A. Stonik, Mona Ghias, Cathy L. Knapper, Maureen L. Sampson, Cuilian Dai, Stewart J. Levine, Alan T. Remaley
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Journal of Lipid Research
Subjects:
endothelial cells
cholesterol efflux
reverse cholesterol transport
high density lipoprotein
ATP binding cassette transporter A1
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520408090

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http://www.sciencedirect.com/science/article/pii/S0022227520408090

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