Antitumor immunity of DNA vaccine based on CTLA-4 fused with HER2 against colon carcinoma
Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) negatively regulates the T cell activation and competes with CD28 in binding with B7.1/B7.2 molecules. Fusion of the extracellular region of CTLA-4 and a specific antigen is an effective method for improving the immune efficacy of DNA vaccines. Th...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2018-04-01
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| Series: | European Journal of Inflammation |
| Online Access: | https://doi.org/10.1177/2058739218768144 |