Genetic background modifies phenotypic and transcriptional responses in a C. elegans model of α-synuclein toxicity

Genetic background modifies phenotypic and transcriptional responses in a C. elegans model of α-synuclein toxicity

Abstract Background Accumulation of protein aggregates are a major hallmark of progressive neurodegenerative disorders such as Parkinson’s disease and Alzheimer’s disease. Transgenic Caenorhabditis elegans nematodes expressing the human synaptic protein α-synuclein in body wall muscle show inclusion...

Full description

Bibliographic Details
Main Authors: Yiru A. Wang, Basten L. Snoek, Mark G. Sterken, Joost A. G. Riksen, Jana J. Stastna, Jan E. Kammenga, Simon C. Harvey
Format: Article
Language:English
Published: BMC 2019-03-01
Series:BMC Genomics
Subjects:
Natural variation
Gene expression profile
Protein aggregation
α-Synuclein
Genetic background
Caenorhabditis elegans
Online Access:http://link.springer.com/article/10.1186/s12864-019-5597-1

Internet

http://link.springer.com/article/10.1186/s12864-019-5597-1

Similar Items