Increased glial glutamate transporter EAAT2 expression reduces epileptogenic processes following pilocarpine-induced status epilepticus

Several lines of evidence indicate that glutamate plays a crucial role in the initiation of seizures and their propagation; abnormal glutamate release causes synchronous firing of large populations of neurons, leading to seizures. In the present study, we investigated whether enhanced glutamate upta...

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Bibliographic Details
Main Authors: Qiongman Kong, Kou Takahashi, Delanie Schulte, Nathan Stouffer, Yuchen Lin, Chien-Liang Glenn Lin
Format: Article
Language:English
Published: Elsevier 2012-08-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112001210