FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase

Dopaminergic neurons are important for regulating energy homeostasis. Here, the authors show the transcription factor FoxO1 negatively regulates tyrosine hydroxylase expression in midbrain dopaminergic neurons, and plays an important role in regulation of glucose homeostasis, energy expenditure, and...

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Main Authors:	Khanh V. Doan, Ann W. Kinyua, Dong Joo Yang, Chang Mann Ko, Sang Hyun Moh, Ko Eun Shong, Hail Kim, Sang-Kyu Park, Dong-Hoon Kim, Inki Kim, Ji-Hye Paik, Ronald A. DePinho, Seul Gi Yoon, Il Yong Kim, Je Kyung Seong, Yun-Hee Choi, Ki Woo Kim
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms12733

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spelling	doaj-3e52e79bfcb5442bbccc4038ce9593812021-05-11T10:51:02ZengNature Publishing GroupNature Communications2041-17232016-09-017111210.1038/ncomms12733FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylaseKhanh V. Doan0Ann W. Kinyua1Dong Joo Yang2Chang Mann Ko3Sang Hyun Moh4Ko Eun Shong5Hail Kim6Sang-Kyu Park7Dong-Hoon Kim8Inki Kim9Ji-Hye Paik10Ronald A. DePinho11Seul Gi Yoon12Il Yong Kim13Je Kyung Seong14Yun-Hee Choi15Ki Woo Kim16Department of Pharmacology, Wonju College of Medicine, Yonsei UniversityDepartment of Pharmacology, Wonju College of Medicine, Yonsei UniversityDepartment of Pharmacology, Wonju College of Medicine, Yonsei UniversityDepartment of Pharmacology, Wonju College of Medicine, Yonsei UniversityAnti-aging Research Institute of BIO-FD&C Co. Ltd.Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and TechnologyGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and TechnologyDepartment of Biochemistry, College of Medicine, Catholic Kwandong UniversityDepartment of Pharmacology, Korea University College of MedicineAsan Institute for Life Sciences, Asan Medical CenterDepartment of Pathology and Laboratory Medicine, Weill Cornell Medical CollegeDepartment of Cancer Biology, University of Texas MD Anderson Cancer CenterLaboratory of Developmental Biology and Genetics, College of Veterinary Medicine, Research Institute for Veterinary ScienceLaboratory of Developmental Biology and Genetics, College of Veterinary Medicine, Research Institute for Veterinary ScienceLaboratory of Developmental Biology and Genetics, College of Veterinary Medicine, Research Institute for Veterinary ScienceAnti-aging Research Institute of BIO-FD&C Co. Ltd.Department of Pharmacology, Wonju College of Medicine, Yonsei UniversityDopaminergic neurons are important for regulating energy homeostasis. Here, the authors show the transcription factor FoxO1 negatively regulates tyrosine hydroxylase expression in midbrain dopaminergic neurons, and plays an important role in regulation of glucose homeostasis, energy expenditure, and resistance to diet-induced obesity.https://doi.org/10.1038/ncomms12733
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Khanh V. Doan Ann W. Kinyua Dong Joo Yang Chang Mann Ko Sang Hyun Moh Ko Eun Shong Hail Kim Sang-Kyu Park Dong-Hoon Kim Inki Kim Ji-Hye Paik Ronald A. DePinho Seul Gi Yoon Il Yong Kim Je Kyung Seong Yun-Hee Choi Ki Woo Kim
spellingShingle	Khanh V. Doan Ann W. Kinyua Dong Joo Yang Chang Mann Ko Sang Hyun Moh Ko Eun Shong Hail Kim Sang-Kyu Park Dong-Hoon Kim Inki Kim Ji-Hye Paik Ronald A. DePinho Seul Gi Yoon Il Yong Kim Je Kyung Seong Yun-Hee Choi Ki Woo Kim FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase Nature Communications
author_facet	Khanh V. Doan Ann W. Kinyua Dong Joo Yang Chang Mann Ko Sang Hyun Moh Ko Eun Shong Hail Kim Sang-Kyu Park Dong-Hoon Kim Inki Kim Ji-Hye Paik Ronald A. DePinho Seul Gi Yoon Il Yong Kim Je Kyung Seong Yun-Hee Choi Ki Woo Kim
author_sort	Khanh V. Doan
title	FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase
title_short	FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase
title_full	FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase
title_fullStr	FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase
title_full_unstemmed	FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase
title_sort	foxo1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-09-01
description	Dopaminergic neurons are important for regulating energy homeostasis. Here, the authors show the transcription factor FoxO1 negatively regulates tyrosine hydroxylase expression in midbrain dopaminergic neurons, and plays an important role in regulation of glucose homeostasis, energy expenditure, and resistance to diet-induced obesity.
url	https://doi.org/10.1038/ncomms12733
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FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase

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