Emodin Protects Against Concanavalin A-Induced Hepatitis in Mice Through Inhibiting Activation of the p38 MAPK-NF-κB Signaling Pathway

Emodin Protects Against Concanavalin A-Induced Hepatitis in Mice Through Inhibiting Activation of the p38 MAPK-NF-κB Signaling Pathway

Background/Aims: To investigate the effects of emodin on concanavalin A (Con A)-induced hepatitis in mice and to elucidate its underlying molecular mechanisms. Methods: A fulminant hepatitis model was established successfully by the intravenous administration of Con A (20 mg/kg) to male Balb/c mice....

Full description

Bibliographic Details
Main Authors: Jihua Xue, Feng Chen, Jing Wang, Shanshan Wu, Min Zheng, Haihong Zhu, Yanning Liu, Jiliang He, Zhi Chen
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-03-01
Series:Cellular Physiology and Biochemistry
Subjects:
Emodin
Con A
Cytokines
Chemokines
p38 MAPK
NF-κB
Immune cells
Online Access:http://www.karger.com/Article/FullText/373971

Internet

http://www.karger.com/Article/FullText/373971

Similar Items