Therapeutic Effect of Endothelin-Converting Enzyme Inhibitor on Chronic Kidney Disease through the Inhibition of Endoplasmic Reticulum Stress and the NLRP3 Inflammasome

Therapeutic Effect of Endothelin-Converting Enzyme Inhibitor on Chronic Kidney Disease through the Inhibition of Endoplasmic Reticulum Stress and the NLRP3 Inflammasome

Chronic inflammation and oxidative stress significantly contribute to the development and progression of chronic kidney disease (CKD). The NOD-like receptor family pyrin containing domain-3 (NLRP3) inflammasome plays a key role in the inflammatory response. The renal endothelin (ET) system is activa...

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Bibliographic Details
Main Authors: Yung-Ho Hsu, Cai-Mei Zheng, Chu-Lin Chou, Yi-Jie Chen, Yu-Hsuan Lee, Yuh-Feng Lin, Hui-Wen Chiu
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Biomedicines
Subjects:
chronic kidney disease
endothelin-converting enzymes
endoplasmic reticulum stress
autophagy
inflammasome
Online Access:https://www.mdpi.com/2227-9059/9/4/398

Internet

https://www.mdpi.com/2227-9059/9/4/398

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