Prophylactic and Therapeutic Effects of Interleukin-2 (IL-2)/Anti-IL-2 Complexes in Systemic Lupus Erythematosus-Like Chronic Graft-Versus-Host Disease

Prophylactic and Therapeutic Effects of Interleukin-2 (IL-2)/Anti-IL-2 Complexes in Systemic Lupus Erythematosus-Like Chronic Graft-Versus-Host Disease

Murine chronic graft-versus-host-disease (cGvHD) induced by injection of parental lymphocytes into F1 hybrids results in a disease similar to systemic lupus erythematosus. Here, we have used DBA/2 T cell injection into (C57BL/6 × DBA/2)F1 (BDF1) mice as a model system to test the prophylactic and th...

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Bibliographic Details
Main Authors: Stefan Heiler, Jonas Lötscher, Matthias Kreuzaler, Johanna Rolink, Antonius Rolink
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Immunology
Subjects:
chronic graft-versus-host-disease
interleukin-2/anti-interleukin-2 complexes
lupus
host regulatory T cells
donor CD8+ T cells
interleukin-2 receptor
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00656/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00656/full

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