Structural basis for recognition of the malaria vaccine candidate Pfs48/45 by a transmission blocking antibody

Structural basis for recognition of the malaria vaccine candidate Pfs48/45 by a transmission blocking antibody

Pfs48/45 is a promising component for a transmission-blocking malaria vaccine. Here, the authors develop a system to produce full-length Pfs48/45 for immunisation, characterise a panel of monoclonal antibodies and determine the structure of a potent transmission-blocking epitope.

Bibliographic Details
Main Authors: Frank Lennartz, Florian Brod, Rebecca Dabbs, Kazutoyo Miura, David Mekhaiel, Arianna Marini, Matthijs M. Jore, Max M. Søgaard, Thomas Jørgensen, Willem A. de Jongh, Robert W. Sauerwein, Carole A. Long, Sumi Biswas, Matthew K. Higgins
Format: Article
Language:English
Published: Nature Publishing Group 2018-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06340-9

Internet

https://doi.org/10.1038/s41467-018-06340-9

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