A liposomal RNA vaccine inducing neoantigen-specific CD4+ T cells augments the antitumor activity of local radiotherapy in mice
Antigen-encoding, lipoplex-formulated RNA (RNA-LPX) enables systemic delivery to lymphoid compartments and selective expression in resident antigen-presenting cells. We report here that the rejection of CT26 tumors, mediated by local radiotherapy (LRT), is further augmented in a CD8+ T cell-dependen...
Main Authors: | Nadja Salomon, Fulvia Vascotto, Abderaouf Selmi, Mathias Vormehr, Juliane Quinkhardt, Thomas Bukur, Barbara Schrörs, Martin Löewer, Mustafa Diken, Özlem Türeci, Ugur Sahin, Sebastian Kreiter |
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Format: | Article |
Language: | English |
Published: |
Taylor & Francis Group
2020-01-01
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Series: | OncoImmunology |
Subjects: | |
Online Access: | http://dx.doi.org/10.1080/2162402X.2020.1771925 |
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