Mutanome Engineered RNA Immunotherapy: Towards Patient-Centered Tumor Vaccination

by Mathias Vormehr, Barbara Schrörs, Sebastian Boegel, Martin Löwer, Özlem Türeci, Ugur Sahin
Published 2015-01-01

mRNA therapeutics in cancer immunotherapy

by Jan D. Beck, Daniel Reidenbach, Nadja Salomon, Ugur Sahin, Özlem Türeci, Mathias Vormehr, Lena M. Kranz
Published 2021-04-01

Targeting the tumor vasculature with engineered cystine-knot miniproteins

by Bonny Gaby Lui, Nadja Salomon, Joycelyn Wüstehube-Lausch, Matin Daneschdar, Hans-Ulrich Schmoldt, Özlem Türeci, Ugur Sahin
Published 2020-01-01

Luciferase mRNA Transfection of Antigen Presenting Cells Permits Sensitive Nonradioactive Measurement of Cellular and Humoral Cytotoxicity

by Tana A. Omokoko, Uli Luxemburger, Shaheer Bardissi, Petra Simon, Magdalena Utsch, Andrea Breitkreuz, Özlem Türeci, Ugur Sahin
Published 2016-01-01

HPV16 RNA-LPX vaccine mediates complete regression of aggressively growing HPV-positive mouse tumors and establishes protective T cell memory

by Christian Grunwitz, Nadja Salomon, Fulvia Vascotto, Abderaouf Selmi, Thomas Bukur, Mustafa Diken, Sebastian Kreiter, Özlem Türeci, Ugur Sahin
Published 2019-09-01

Enhanced stability of a chimeric hepatitis B core antigen virus-like-particle (HBcAg-VLP) by a C-terminal linker-hexahistidine-peptide

by Jens Schumacher, Tijana Bacic, René Staritzbichler, Matin Daneschdar, Thorsten Klamp, Philipp Arnold, Sabrina Jägle, Özlem Türeci, Jürgen Markl, Ugur Sahin
Published 2018-04-01

Intravenous delivery of the toll-like receptor 7 agonist SC1 confers tumor control by inducing a CD8+ T cell response

by Fulvia Vascotto, Jutta Petschenka, Kerstin C. Walzer, Mathias Vormehr, Magdalena Brkic, Stefan Strobl, Roman Rösemann, Mustafa Diken, Sebastian Kreiter, Özlem Türeci, Ugur Sahin
Published 2019-07-01

A liposomal RNA vaccine inducing neoantigen-specific CD4+ T cells augments the antitumor activity of local radiotherapy in mice

by Nadja Salomon, Fulvia Vascotto, Abderaouf Selmi, Mathias Vormehr, Juliane Quinkhardt, Thomas Bukur, Barbara Schrörs, Martin Löewer, Mustafa Diken, Özlem Türeci, Ugur Sahin, Sebastian Kreiter
Published 2020-01-01

Confidence-based somatic mutation evaluation and prioritization.

by Martin Löwer, Bernhard Y Renard, Jos de Graaf, Meike Wagner, Claudia Paret, Christoph Kneip, Ozlem Türeci, Mustafa Diken, Cedrik Britten, Sebastian Kreiter, Michael Koslowski, John C Castle, Ugur Sahin
Published 2012-01-01

Dexamethasone premedication suppresses vaccine-induced immune responses against cancer

by Mathias Vormehr, Sophie Lehar, Lena M. Kranz, Siri Tahtinen, Yoko Oei, Vincent Javinal, Lélia Delamarre, Kerstin C. Walzer, Mustafa Diken, Sebastian Kreiter, Ira Mellman, Ugur Sahin, Jill M. Schartner, Özlem Türeci
Published 2020-01-01

A non-functional neoepitope specific CD8+ T-cell response induced by tumor derived antigen exposure in vivo

by Mathias Vormehr, Katharina Reinhard, Renata Blatnik, Kathrin Josef, Jan David Beck, Nadja Salomon, Martin Suchan, Abderraouf Selmi, Fulvia Vascotto, Johannes Zerweck, Holger Wenschuh, Mustafa Diken, Sebastian Kreiter, Özlem Türeci, Angelika B. Riemer, Ugur Sahin
Published 2019-03-01

561 DuoBody®-PD-L1×4–1BB (GEN1046) induces superior immune-cell activation, cytokine production and cytotoxicity by combining PD-L1 blockade with conditional 4–1BB co-stimulation...

by Maria Jure-Kunkel, Rachelle Kosoff, Mark Fereshteh, Alexander Muik, Isil Altintas, Friederike Gieseke, Kristina Schödel, Theodora Salcedo, Saskia Burm, Aras Toker, Lena Kranz, Mathias Vormehr, David Eisel, Özlem Türeci, Esther Breij, Tahamtan Ahmadi, Ugur Sahin
Published 2020-11-01