Implementation of whole genome sequencing for tuberculosis diagnostics in a low-middle income, high MDR-TB burden country

Abstract Whole genome sequencing (WGS) is revolutionary for diagnostics of TB and its mutations associated with drug-resistances, but its uptake in low- and middle-income countries is hindered by concerns of implementation feasibility. Here, we provide a proof of concept for its successful implement...

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Bibliographic Details
Main Authors: Monica Vogel, Christian Utpatel, Caroline Corbett, Thomas A. Kohl, Altyn Iskakova, Sevim Ahmedov, Uladzimir Antonenka, Viola Dreyer, Ainura Ibrahimova, Chynara Kamarli, Dilorom Kosimova, Vanessa Mohr, Evgeni Sahalchyk, Meerim Sydykova, Nagira Umetalieva, Abdylat Kadyrov, Gulmira Kalmambetova, Stefan Niemann, Harald Hoffmann
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-94297-z