T cell dynamics and response of the microbiota after gene therapy to treat X-linked severe combined immunodeficiency

T cell dynamics and response of the microbiota after gene therapy to treat X-linked severe combined immunodeficiency

Abstract Background Mutation of the IL2RG gene results in a form of severe combined immune deficiency (SCID-X1), which has been treated successfully with hematopoietic stem cell gene therapy. SCID-X1 gene therapy results in reconstitution of the previously lacking T cell compartment, allowing analys...

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Main Authors: Erik L. Clarke, A. Jesse Connell, Emmanuelle Six, Nadia A. Kadry, Arwa A. Abbas, Young Hwang, John K. Everett, Casey E. Hofstaedter, Rebecca Marsh, Myriam Armant, Judith Kelsen, Luigi D. Notarangelo, Ronald G. Collman, Salima Hacein-Bey-Abina, Donald B. Kohn, Marina Cavazzana, Alain Fischer, David A. Williams, Sung-Yun Pai, Frederic D. Bushman
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Genome Medicine
Online Access:http://link.springer.com/article/10.1186/s13073-018-0580-z

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http://link.springer.com/article/10.1186/s13073-018-0580-z

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