Molecular Characterisation of the Haemagglutinin Glycan-Binding Specificity of Egg-Adapted Vaccine Strains of the Pandemic 2009 H1N1 Swine Influenza A Virus

Molecular Characterisation of the Haemagglutinin Glycan-Binding Specificity of Egg-Adapted Vaccine Strains of the Pandemic 2009 H1N1 Swine Influenza A Virus

The haemagglutinin (HA) glycan binding selectivity of H1N1 influenza viruses is an important determinant for the host range of the virus and egg-adaption during vaccine production. This study integrates glycan binding data with structure-recognition models to examine the impact of the K123N, D225G a...

Full description

Bibliographic Details
Main Authors: Vincenzo Carbone, Elena K. Schneider, Steve Rockman, Mark Baker, Johnny X. Huang, Chi Ong, Matthew A. Cooper, Elizabeth Yuriev, Jian Li, Tony Velkov
Format: Article
Language:English
Published: MDPI AG 2015-06-01
Series:Molecules
Subjects:
pandemic H1N1 swine influenza A virus
haemagglutinin
glycan binding specificity
egg-adaption
Online Access:http://www.mdpi.com/1420-3049/20/6/10415

Internet

http://www.mdpi.com/1420-3049/20/6/10415

Similar Items