CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection

CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection

The co-stimulatory molecule CD28 is essential for activation of helper T cells. Despite this critical role, it is not known whether CD28 has functions in maintaining T cell responses following activation. To determine the role for CD28 after T cell priming, we generated a strain of mice where CD28 i...

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Bibliographic Details
Main Authors: Michelle A Linterman, Alice E Denton, Devina P Divekar, Ilona Zvetkova, Leanne Kane, Cristina Ferreira, Marc Veldhoen, Simon Clare, Gordon Dougan, Marion Espéli, Kenneth GC Smith
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-10-01
Series:eLife
Subjects:
CD28
helper T cell
infection
Online Access:https://elifesciences.org/articles/03180

Internet

https://elifesciences.org/articles/03180

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