Cellular internalization of bystander nanomaterial induced by TAT-nanoparticles and regulated by extracellular cysteine

To enter the cells, nanomaterials often need covalent conjugation with cell-penetrating ligands such as TAT. Here, the authors show that simple mixing with TAT-coupled nanoparticles enables the cellular uptake of unfunctionalized nanoparticles, and its activity is stimulated by cysteine in the mediu...

Full description

Bibliographic Details
Main Authors: Yushuang Wei, Tang Tang, Hong-Bo Pang
Format: Article
Language:English
Published: Nature Publishing Group 2019-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11631-w